Short Communication Endothelial Nitric Oxide Modulates Expression and Processing of Amyloid Precursor Protein
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چکیده
of APP expression and processing in vivo, we used brain and cerebral microvessels from eNOS-deficient (eNOS / ) mice. Brain tissue from eNOS / mice had statistically higher APP and BACE1 protein levels, as well as increased BACE1 enzyme activity and A (A 1-42 wild-type control, 0.737pg/mg; eNOS / , 1.475 pg/mg; P<0.05), compared with wild-type controls (n 6 to 8 animals per background). Brain microvessels from eNOS / mice also showed statistically higher BACE1 protein levels as compared with wild-type control. Conclusions: Our data suggest that endothelial NO plays an important role in modulating APP expression and
منابع مشابه
Endothelial nitric oxide modulates expression and processing of amyloid precursor protein.
RATIONALE the exact etiology of sporadic Alzheimer disease (AD) is unclear, but it is interesting that several cardiovascular risk factors are associated with higher incidence of AD. The link between these risk factors and AD has yet to be identified; however, a common feature is endothelial dysfunction, specifically, decreased bioavailability of nitric oxide (NO). OBJECTIVE to determine the ...
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